Publications

NOVEMBER 15, 2017
Towards natural mimetics of metformin and rapamycin
Aging is now at the forefront of major challenges faced globally, creating an immediate need for safe, widescale interventions to reduce the burden of chronic disease and extend human healthspan.
NOVEMBER 9, 2017
Converging blockchain and next-generation artificial intelligence technologies to decentralize and accelerate biomedical research and healthcare
The increased availability of data and recent advancements in artificial intelligence present the unprecedented opportunities in healthcare and major challenges for the patients, developers, providers and regulators. The novel deep learning and transfer learning techniques are turning any data about the person into medical data transforming simple facial pictures and videos into powerful sources of data for predictive analytics.
28 SEPTEMBER, 2017
Induced Cell Turnover: A Novel Therapeutic Modality for In Situ Tissue Regeneration
Written and published by Biogerontology Research Foundation staff in collaboration with Northwestern University Feinberg School of Medicine, the Neurobiology Department of Swammerdam Institute of Life Sciences at the University of Amsterdam and the Department of Biomedical and Molecular Sciences of Queen's University School of Medicine, Queen's University
SEPTEMBER 5, 2017
druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico
Deep generative adversarial networks (GANs) are the emerging technology in drug discovery and biomarker development. In our recent work, we demonstrated a proof-of-concept of implementing deep generative adversarial autoencoder (AAE) to identify new molecular fingerprints with predefined anticancer properties.
JUNE 16, 2017
The DrugAge database of aging-related drugs
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds that extend lifespan in model organisms is a growing research area. Here, we present DrugAge (http://genomics.senescence.info/drugs/), a curated database of lifespan-extending drugs and compounds
MAY 22, 2017
In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia
A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often visually identified as leukoplakia) prior to cancer diagnosis.
FEBRUARY 14, 2017
The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology
Recent advances in deep learning and specifically in generative adversarial networks have demonstrated surprising results in generating new images and videos upon request even using natural language as input.
September 28, 2016
Design of efficient computational workflows for in silico drug repurposing. Drug Discov Today.
Written and published by Biogerontology Research Foundation staff in collaboration with BioTime Inc., Insilico Medicine Inc. and Johns Hopkins University. Authors: Vanhaelen Q, Mamoshina P, Aliper AM, Artemov A, Lezhnina K, Ozerov I, Labat I, Zhavoronkov A.
September 24, 2016
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state.
Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc., Pathway Pharmaceuticals, Ltd., Center for Biogerontology and Regenerative Medicine, Moscow Institute of Physics and Technology, University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), D. Rogachev Federal Research and Clinical Center for Pediatric Hematology, Oncology, and Immunology, Life Extension, George Mason University (School of Systems Biology), and the Engelhardt Institute of Molecular Biology of Russian Academy of Sciences. Authors: Aliper A, Belikov AV, Garazha A, Jellen L, Artemov A, Suntsova M, Ivanova A, Venkova L, Borisov N, Buzdin A, Mamoshina P, Putin E, Swick AG, Moskalev A, Zhavoronkov A.
July 5, 2016
Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data. Mol Pharm.
Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc., The Mind Research Network and Datalytic Solutions. Authors: Aliper A, Plis S, Artemov A, Ulloa A, Mamoshina P, Zhavoronkov A.
July 2, 2016
Common pathway signature in lung and liver fibrosis. Cell Cycle.
Written and published by Biogerontology Research Foundation staff in collaboration with Wake Forest Institute for Regenerative Medicine (Wake Forest School of Medicine), Atlas Regeneration Inc. and Johns Hopkins University. Authors: Makarev E, Izumchenko E, Aihara F, Wysocki PT, Zhu Q, Buzdin A, Sidransky D, Zhavoronkov A, Atala A.
June 17, 2016
Pro-fibrotic pathway activation in trabecular meshwork and lamina cribrosa is the main driving force of glaucoma. Cell Cycle.
Written and published by Biogerontology Research Foundation staff in collaboration with Biotime, Inc., Johns Hopkins University, Howard University (Epigenetics Laboratory), Retrope, Inc., Vision Genomics, Inc., and Insilico Medicine, Inc. Authors: Zhavoronkov A, Kanherkar RR, Izumchenko E, Teka M, Cantor C, Manaye K, Sidransky D, West MD, Makarev E, Csoka AB.
June 15, 2016
Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic. Aging Cell.
Written and published by Biogerontology Research Foundation staff in collaboration with the Buck Institute for Research on Aging, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Moscow Institute of Physics and Technology, Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology and 5Institute for Systems Analysis, Russian Academy of Sciences. Authors: Moskalev A, Chernyagina E, Tsvetkov V, Fedintsev A, Shaposhnikov M, Krut'ko V, Zhavoronkov A, Kennedy BK.
May 8, 2016
Deep biomarkers of human aging: Application of deep neural networks to biomarker development. Aging (Albany NY).
Written and published by Biogerontology Research Foundation staff in collaboration with Albert Einstein College of Medicine (Department of Genetics), Boston University (Department of Biomedical Engineering), George Mason University (School of Systems Biology), Insilico Medicine, Inc. (Pharma.AI Department), ITMO University (Computer Technologies Lab), and Invitro Laboratory, Ltd. Authors: Putin E, Mamoshina P, Aliper A, Korzinkin M, Moskalev A, Kolosov A, Ostrovskiy A, Cantor C, Vijg J, Zhavoronkov A.
February 16, 2016
Editorial: Should We Treat Aging as a Disease? Academic, Pharmaceutical, Healthcare Policy, and Pension Fund Perspectives. Front Genet.
Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine Inc. Authors: Zhavoronkov A, Moskalev A.
January 4, 2016
Aging Chart: a community resource for rapid exploratory pathway analysis of age-related processes. Nucleic Acids Res.
Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Laboratory of Genetics of Aging and Longevity), Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences (Laboratory of Molecular Radiobiology and Gerontology), Estonia Infinity Sciences, Inc., University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), and D.Rogachev FRC Center for Pediatric Hematology, Oncology and Immunology. Authors: Moskalev A, Zhikrivetskaya S, Shaposhnikov M, Dobrovolskaya E, Gurinovich R, Kuryan O, Pashuk A, Jellen LC, Aliper A, Peregudov A, Zhavoronkov A.
November 30, 2015
Interactome analysis of myeloid-derived suppressor cells in murine models of colon and breast cancer. Oncotarget.
Written and published by Biogerontology Research Foundation staff in collaboration with HiBiotechnology LLC and Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology. Authors: Aliper AM, Frieden-Korovkina VP, Buzdin A, Roumiantsev SA, Zhavoronkov A.
November 4, 2015
Classifying aging as a disease in the context of ICD-11. Front Genet.
Written and published by Biogerontology Research Foundation staff in collaboration with Novartis Pharma AG, Department of Developmental and Molecular Pathways, Novartis Institute for Biomedical Research. Authors: Zhavoronkov A, Bhullar B.
September 29, 2015
Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation. Oncotarget.
Written and published by Biogerontology Research Foundation staff in collaboration with Canadian Nuclear Laboratories, Insilico Medicine Inc., Emanuel Institute for Biochemical Physics (Russian Academy of Sciences), Moscow Institute of Physics and Technology, Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology, Semenov Institute of Chemical Physics (Russian Academy of Sciences) and State Research Center - Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency (SRC-FMBC). Authors: Osipov AN, Grekhova A, Pustovalova M, Ozerov IV, Eremin P, Vorobyeva N, Lazareva N, Pulin A, Zhavoronkov A, Roumiantsev S, Klokov D, Eremin I.
September 15, 2015
Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells. Oncotarget.
Written and published by Biogerontology Research Foundation staff in collaboration with Stanford University Medical Center (Department of Developmental Biology), Ludwig Maximilian University of Munich (Department of Computational Genomics), Ruhr University Bochum (Department of Neurophysiology), Atlas Regeneration, Inc,., and Insilico Medicine, Inc. Authors: Makarev E, Fortney K, Litovchenko M, Braunewell KH, Zhavoronkov A, Atala A.
September 7, 2015
Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY).
Written and published by Biogerontology Research Foundation staff in collaboration with the Buck Institute for Research on Aging, George Mason University (School of Systems Biology), Moscow Institute of Physics and Technology, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences (Laboratory of Postgenomic Studies), Institute of Integrative Biology (Integrative Genomics of Ageing Group). D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, The Judea Regional R&D Center, Pirogov Russian National Research Medical University (, The Research Institute for Translational Medicine ), Insilico Medicine, Inc., Xspansa, University of Tennessee Health Science Center (Institute of Physiologically Active Compounds of Russian Academy of Sciences, Genetics, Genomics, and Informatics) and Infinity Sciences, Inc. Authors: Moskalev A, Chernyagina E, de Magalhães JP, Barardo D, Thoppil H, Shaposhnikov M, Budovsky A, Fraifeld VE, Garazha A, Tsvetkov V, Bronovitsky E, Bogomolov V, Scerbacov A, Kuryan O, Gurinovich R, Jellen LC, Kennedy B, Mamoshina P, Dobrovolskaya E, Aliper A, Kaminsky D, Zhavoronkov A.
June 18, 2015
It is time to classify biological aging as a disease. Front Genet.
Written and published by Biogerontology Research Foundation staff in collaboration with Oxford University (Biochemistry Department), Ghent University and Heales vzw. Authors: Bulterijs S, Hull RS, Björk VC, Roy AG.
February 6, 2015
Screening and personalizing nootropic drugs and cognitive modulator regimens in silico. Front Syst Neurosci.
Written and published by Biogerontology Research Foundation staff in collaboration with University of Tennessee Health Science Center (Department of Genetics, Genomics, and Informatics), Insilico Medicine, Inc. and Pathway Pharmaceuticals Ltd. Authors: Jellen LC, Aliper A, Buzdin A, Zhavoronkov A.
January 20, 2015
Longevity expectations in the pension fund, insurance, and employee benefits industries. Psychol Res Behav Manag.
Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A.
January 7, 2015
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells.
Written and published by Biogerontology Research Foundation staff in collaboration with the Polish Academy of Sciences (Institute of Fundamental Technological Research), Johns Hopkins University, Insilico Medicine, Inc., Howard University (Epigenetics Laboratory), Pirogov Russian National Research Medical University, Pathway Pharmaceuticals Ltd., Moscow Institute of Physics and Technology, and George Mason University. Authors: Aliper AM, Csoka AB, Buzdin A, Jetka T, Roumiantsev S, Moskalev A, Zhavoronkov A.
December 22, 2014
Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.
Written and published by Biogerontology Research Foundation staff in collaboration with Insilico Medicine, Inc., Boston University and Vision Genomics LLC. Authors: Makarev E, Cantor C, Zhavoronkov A, Buzdin A, Aliper A, Csoka AB.
March 6, 2014
Genetics and epigenetics of aging and longevity. Cell Cycle.
Written and published by Biogerontology Research Foundation staff in collaboration with University of California at Davis (Department of Ophthalmology and Vision Science; School of Medicine), Moscow Institute of Physics and Technology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Komi Science Center of Russian Academy of Sciences (Institute of Biology) and Federal Clinical Research Center of Pediatric Hematology, Oncology, and Immunology. Authors: Moskalev AA, Aliper AM, Smit-McBride Z, Buzdin A, Zhavoronkov A.
March 3, 2014
Signaling pathway cloud regulation for in silico screening and ranking of the potential geroprotective drugs. Front Genet.
Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Department of Biological and Medical Physics). Authors: Zhavoronkov A, Buzdin AA, Garazha AV, Borisov NM, Moskalev AA.
January 23, 2014
On multilabel classification methods of incompletely labeled biomedical text data. Comput Math Methods Med.
Written and published by Biogerontology Research Foundation staff in collaboration with Moscow Institute of Physics and Technology (Center for Pediatric Hematology, Oncology, and Immunology) and Moscow State University (Chemistry Department). Authors: Kolesov A, Kamyshenkov D, Litovchenko M, Smekalova E, Golovizin A, Zhavoronkov A.
November 8, 2013
Biomedical progress rates as new parameters for models of economic growth in developed countries. Int J Environ Res Public Health.
Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A, Litovchenko M.
October 18, 2013
From personalized medicine to personalized science: uniting science and medicine for patient-driven, goal-oriented research.
Written and published by Biogerontology Research Foundation staff. Authors: Zhavoronkov A, Cantor CR.
30 NOVEMBER 2015
Democratizing Insights: VITAL Report of the Stem Cell industry
This week, a new semi-automated report by VITAL on the stem cell industry was released.
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