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September 7, 2015

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY).

Written and published by Biogerontology Research Foundation staff in collaboration with the Buck Institute for Research on Aging, George Mason University (School of Systems Biology), Moscow Institute of Physics and Technology, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences (Laboratory of Postgenomic Studies), Institute of Integrative Biology (Integrative Genomics of Ageing Group). D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, The Judea Regional R&D Center, Pirogov Russian National Research Medical University (, The Research Institute for Translational Medicine ), Insilico Medicine, Inc., Xspansa, University of Tennessee Health Science Center (Institute of Physiologically Active Compounds of Russian Academy of Sciences, Genetics, Genomics, and Informatics) and Infinity Sciences, Inc.

Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY). 2015 Sep;7(9):616-28.

Moskalev A(1,2,3,4), Chernyagina E(2), de Magalhães JP(5,6), Barardo D(5), Thoppil H(5), Shaposhnikov M(1), Budovsky A(7,8), Fraifeld VE(7), Garazha A(2,9), Tsvetkov V(2,10), Bronovitsky E(11), Bogomolov V(2), Scerbacov A(12), Kuryan O(12,13), Gurinovich R(12,13), Jellen LC(9,14), Kennedy B(15), Mamoshina P(9,6), Dobrovolskaya E(1), Aliper A(9,16,6), Kaminsky D(6), Zhavoronkov A(9,16,6).

(1) Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar 167982, Russia.

(2) Moscow Institute of Physics and Technology, Dolgoprudny 141700, Russia.

(3) Laboratory of Postgenomic Studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow 119991, Russia.

(4) School of Systems Biology, George Mason University, Manassas, VA 20110, USA.

(5) Integrative Genomics of Ageing Group, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

(6) The Biogerontology Research Foundation, London, UK.

(7) The Shraga Segal Department of Microbiology, Immunology, and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer Sheva, Israel.

(8) The Judea Regional R&D Center, Carmel, Israel.

(9) Insilico Medicine, Inc., ETC, Johns Hopkins University, B301, Baltimore, MD 21218, USA.

(10) The Research Institute for Translational Medicine, Pirogov Russian National Research Medical University, Moscow 117997, Russia.

(11) Institute of Physiologically Active Compounds of Russian Academy of Sciences, Chernogolovka 142432, Russia.

(12) Xpansa, Conzl OU, Tallinn 10616, Estonia.

(13) Infinity Sciences, Inc, Lewes, DE 19958, USA.

(14) Genetics, Genomics, and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

(15) Buck Institute for Research on Aging, Novato, CA 94945, USA.

(16) D. Rogachev Center for Pediatric Hematology, Oncology and Immunology, Moscow, Russia.

Abstract: As the level of interest in aging research increases, there is a growing number of geroprotectors, or therapeutic interventions that aim to extend the healthy lifespan and repair or reduce aging-related damage in model organisms and, eventually, in humans. There is a clear need for a manually-curated database of geroprotectors to compile and index their effects on aging and age-related diseases and link these effects to relevant studies and multiple biochemical and drug databases. Here, we introduce the first such resource, Geroprotectors (http://geroprotectors.org). Geroprotectors is a public, rapidly explorable database that catalogs over 250 experiments involving over 200 known or candidate geroprotectors that extend lifespan in model organisms. Each compound has a comprehensive profile complete with biochemistry, mechanisms, and lifespan effects in various model organisms, along with information ranging from chemical structure, side effects, and toxicity to FDA drug status. These are presented in a visually intuitive, efficient framework fit for casual browsing or in-depth research alike. Data are linked to the source studies or databases, providing quick and convenient access to original data. The Geroprotectors database facilitates cross-study, cross-organism, and cross-discipline analysis and saves countless hours of inefficient literature and web searching. Geroprotectors is a one-stop, knowledge-sharing, time-saving resource for researchers seeking healthy aging solutions.

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